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Mouse models of breast cancer metastasis - Wikiped

Generating mouse models of breast cancer Targeted expression of oncogenes in mouse mammary epithelial cells is a way of modeling human breast cancer. Mutation or over expression of oncogenes can be kept under controlled expression in a very specific ...

Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability | Scien

... (PKA) induce a mesenchymal-to-epithelial transition (MET) in mesenchymal human mammary epithelial cells. PKA activation triggers epigenetic reprogramming of TICs by the histone demethylase PHF2, ...

Biology of the Mammary Gland | John A. Mol | Spring

Proceedings of the European Cooperation in the Field of Scientific and Technical Research (COST 825) Symposium on Mammary Gland Biology, held September 16-18, 1999, in Tours, France. It is difficult to overstate the evolutionary and functional significance ...

Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability | Scien

... (PKA) induce a mesenchymal-to-epithelial transition (MET) in mesenchymal human mammary epithelial cells. PKA activation triggers epigenetic reprogramming of TICs by the histone demethylase PHF2, ...

Metabolic reprogramming and epithelial‐to‐mesenchymal transition in canc

In tissues, epithelial cells are organised in compact layers anchored to the basal lamina. During transformation, ... of Twist1 in human mammary epithelial cells. Among these enzymes, dihydropyrimidine dehydrogenase (DPYD), an enzyme involved in pyrimidine ...

Cyclic AMP regulates formation of mammary epithelial acini in vitro | Molecular Biology of the Ce

Thus, in MCF10A and other mammary epithelial cells, decreased ERK signaling may result from a combination of integrin- and cAMP-dependent effects, ...

Epithelial-Mesenchymal Transitions in Development and Disease: Ce

Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis ...

Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating abili

enables carcinoma cells to acquire malignancy-associated traits and properties of tumor-initiating cells ... (MET) in mesenchymal human mammary epithelial cells. Activation of PKA triggers PHF2-mediated epigenetic reprogramming of TICs This study ...

Targeting the death machinery in mammary epithelial cells: Implications for breast cancer from transgenic and tissue culture experimen

Critical Reviews in Oncology/Hematology 63 (2007) 231–240 Targeting the death machinery in mammary epithelial cells: Implications for breast cancer from transgenic and tissue culture experiments Richard Jager¨ ∗ Department of Developmental Pathology ...

Targeting of PKA in mammary epithelial cells. Mechanisms and functional consequences | Roger A. Clegg | Request P

Request PDF on ResearchGate | Targeting of PKA in mammary epithelial cells. Mechanisms and functional consequences | Targeting of protein kinases, promoting association with specific partner-molecules and localisation to particular sites within the cell, has ...

Abstract C27: Activation of PKA induces a mesenchymal-to-epithelial transition and epigenetic reprogramming-mediated loss of tumor initiating .

Request PDF on ResearchGate | Abstract C27: Activation of PKA induces a mesenchymal-to-epithelial transition and epigenetic reprogramming-mediated loss of tumor initiating ability | Cancer stem cells (CSCs) have emerged in recent years as important targets for ...

Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer: Ce

The tumor suppressor BRCA1 and certain of its partners prevent the aberrant transdifferentiation of mammary epithelial cells to a mesenchymal state by participating in interstrand crosslink DNA repair. ...

(PDF) Development of the mammary gland and lactation | james rillema - Academia.e

Targeting of PKA in Mammary Epithelial Cells By Raphaël Boisgard Heparan Sulphate By Maryse Delehedde Lactogenic hormones stimulate expression of lipogenic genes but not glucose transporters in bovine mammary gland By R. Blauwiekel READ PAPER × ...

Prolactin-induced Subcellular Targeting of GLUT1 Glucose Transporter in Living Mammary Epithelial Cel

GLUT1 Subcellular Targeting in Living Mammary Epithelial Cells Rambam Maimonides Medical Journal 4 October 2015 Volume 6 -subcellular targeting.

Cyclic AMP regulates formation of mammary epithelial acini in vit

Epithelial cells form tubular and acinar structures notable for a hollow lumen. In three-dimensional culture utilizing MCF10A mammary epithelial cells, acini form due to integrin-dependent polarization and survival of cells contacting extracellular matrix (ECM), and the ...

Targeting of PKA in Mammary Epithelial Cells | SpringerLi

Abstract Targeting of protein kinases, promoting association with specific partner-molecules and localisation to particular sites within the cell, has come to be recognised as a key mechanism for attributing specificity to these enzymes. In mammary epithelial cells ...

'Isolation, Culture, and Differentiation of Mammary Epithelial Stem/Progenitor Cells from Fresh or Ex Vivo Cultured Human Breast Tissue'. In .

ISOLATION OF MAMMARY EPITHELIAL STEM/PROGENITOR CELLS BY FLOW CYTOMETRY SORTING In this protocol, single cells are labeled with antibodies targeting cell surface markers and sorted by flow cytometry as described by Stingl and co-workers ...

(PDF) Targeting of PKA in Mammary Epithelial Cells | Raphaël Boisgard - Academia.e

pdf Targeting of PKA in Mammary Epithelial Cells Advances in Experimental Medicine and Biology, 2002 Raphaël Boisgard F. Laviale Roger Clegg M. Olivier-bousquet Raphaël Boisgard F. Laviale Roger Clegg M. Olivier-bousquet Download with Google or ...

MicroRNA-221 regulates proliferation of bovine mammary gland epithelial cells by targeting the STAT5a and IRS1 genes - ScienceDire

MicroRNA-221 regulates proliferation of bovine mammary gland epithelial cells by targeting the STAT5a and IRS1 genes Author links open overlay panel B.L. Jiao a X.L. Zhang a S.H. Wang a L ...

Epithelial-Mesenchymal Plasticity in Cancer Progression and Metastasis - ScienceDire

Epithelial-to-mesenchymal transition (EMT) and its reversed process, mesenchymal-to-epithelial transition (MET), are fundamental processes in embryonic development and tissue repair but confer malignant properties to carcinoma cells, including invasive behavior ...

MiR-139 suppresses β-casein synthesis and proliferation in bovine mammary epithelial cells by targeting the GHR and IGF1R signaling pathwa

proliferation in bovine mammary epithelial cells by targeting the GHR and IGF1R signaling pathways Yingjun Cui1,2, Xia Sun1, Lianfeng Jin1, Guangpu Yu1, Qingzhang Li1, Xuejun Gao1, Jinxia Ao2 and Chunmei Wang1* ...